At what timeframe postpartum is the use of COCs and Transdermal patch contraindicated if there are other risk factors for VTE?

The use of combined oral contraceptives (COCs) and the transdermal patch is contraindicated in the postpartum period for women with additional risk factors for venous thromboembolism (VTE) during the first 21 days after delivery. During this time, the risk of developing VTE is significantly heightened due to physiological changes such as increased clotting factors and venous stasis associated with pregnancy and the immediate postpartum period.

While 21 to 42 days postpartum may see a gradual decrease in VTE risk, continued contraindication for those with additional risk factors remains essential. After 42 days postpartum, the risk stabilizes and women with other risk factors may generally initiate COCs or patch use more safely, although individual assessments should always guide decision-making.

This understanding is rooted in guidelines emphasizing careful consideration of thrombosis risks, particularly for new mothers, as they transition from pregnancy into the postpartum period. Therefore, the identified timeframe highlights the critical window where vigilance is needed to mitigate the risks of thromboembolic events, aligning with clinical safety recommendations post childbirth.