Is buprenorphine safe to use during pregnancy?

Buprenorphine is considered safe to use during pregnancy and breastfeeding, particularly in the context of treating opioid use disorder. It is classified as a Category C medication by the FDA, which means that while animal reproduction studies have shown an adverse effect on the fetus, there are no adequate and well-controlled studies in pregnant women. However, the benefits of treating opioid dependence in pregnant individuals often outweigh the potential risks to the fetus.

Using buprenorphine has been associated with positive outcomes in limited studies, including a lower likelihood of neonatal withdrawal syndrome compared to full agonist opioids. It is important to manage opioid dependence effectively to reduce risks associated with relapse, which can lead to unsafe behavior or inadequate prenatal care, both of which can endanger maternal and fetal health.

The options suggesting contraindications or limited use to specific trimesters do not reflect current clinical guidance and findings. Buprenorphine provides a safer alternative for managing opioid dependence than many other substances, contributing to better overall health outcomes for both mothers and their babies.