What are the contraindications associated with the use of bupropion?

Bupropion, an atypical antidepressant often used for major depressive disorder and smoking cessation, has specific contraindications that are crucial for patient safety. It is particularly contraindicated in individuals with a history of seizure disorders and eating disorders like anorexia or bulimia. This is because bupropion lowers the seizure threshold, meaning it can increase the risk of seizures in these populations.

For those with eating disorders, the risk is compounded due to electrolyte imbalances that can occur, further heightening the likelihood of seizure activity. Therefore, healthcare providers must screen for these conditions when prescribing bupropion to ensure that patients do not have an increased risk of adverse effects.

Considering the other options, liver disease and myocardial infarction may present risks or necessitate caution, but they are not absolute contraindications like seizure disorders and eating disorders are for bupropion. While dizziness and headaches can occur as side effects, they do not constitute contraindications and typically do not prevent the use of the medication in the absence of the specified disorders.