What is a significant side effect of thiazolidinediones?

Thiazolidinediones (TZDs) are a class of medications used primarily to manage type 2 diabetes. A notable side effect associated with this class of drugs is weight gain. This phenomenon occurs because TZDs work by increasing insulin sensitivity in muscle and adipose tissues, which can lead to an increase in fat storage. Additionally, these medications may cause fluid retention, further contributing to weight gain.

The weight gain associated with TZDs can be significant and is an important factor for healthcare providers to consider when prescribing these medications, especially in patients who may already be struggling with obesity or weight-related health issues. In clinical practice, addressing lifestyle changes alongside pharmacotherapy is crucial for ensuring optimal treatment outcomes for patients using thiazolidinediones.