What is often elevated in liver function tests (LFTs) in cases of infectious mononucleosis?

In cases of infectious mononucleosis, liver function tests often show an elevation in alkaline phosphatase levels. This enzyme is associated with the biliary system but can also be elevated in various liver diseases, particularly those involving inflammation or obstruction. In infectious mononucleosis, which is commonly caused by Epstein-Barr virus (EBV), liver involvement can occur, leading to a mild elevation of alkaline phosphatase.

Elevated bilirubin levels can occur but are less characteristic of infectious mononucleosis specifically when compared to alkaline phosphatase elevation. Bilirubin elevation typically indicates more severe liver dysfunction or biliary obstruction. On the other hand, glucose levels generally remain stable and are not directly impacted by infectious mononucleosis. Albumin levels are also not usually elevated in this context; instead, they may be normal or slightly low if there is significant liver dysfunction.

Overall, the considerable elevation in alkaline phosphatase reflects the liver's response to the viral infection and helps guide the clinical assessment of liver function in patients with infectious mononucleosis.