What is the primary action of meglitinides such as repaglinide?

Meglitinides, such as repaglinide, primarily work by stimulating the pancreas to release insulin in response to meals. This mechanism is essential for managing blood glucose levels in individuals with type 2 diabetes. By acting on pancreatic beta cells, meglitinides prompt a rapid and short-lived increase in insulin secretion, which helps to lower blood sugar levels after eating.

This insulin secretion is influenced by the presence of glucose, making the action of meglitinides particularly effective when taken before meals. Their quick onset and duration of action align with postprandial glucose management, making them a useful therapeutic option for controlling blood sugar spikes that occur after meals.

In contrast, other options focus on different mechanisms unrelated to the primary action of meglitinides. While increasing insulin sensitivity, inhibiting glucose production in the liver, or increasing incretin levels are important strategies in diabetes management, they do not describe the specific action of meglitinides like repaglinide.