What signs might indicate the severity of infection in infectious mononucleosis?

Lymphadenopathy, or swollen lymph nodes, is a hallmark sign of infectious mononucleosis, particularly when it is extensive and involves lymph nodes in multiple regions, such as the neck, armpits, and groin. The presence and severity of lymphadenopathy help indicate the underlying immune response to the Epstein-Barr virus, which causes the condition.

In infectious mononucleosis, significant lymphadenopathy, especially if it is generalized and associated with accompanying symptoms like sore throat, fever, and fatigue, highlights a more severe systemic infection. This response can reflect the degree of viral replication and immune system engagement. Close monitoring of lymphadenopathy can be clinically valuable in assessing the patient's condition and guiding management.

Other options presented do not provide the same level of diagnostic insight. For instance, palpable lymph nodes in the groin can occur in various other infections or conditions and are not specific to the severity of infectious mononucleosis. Clear nasal discharge is generally associated with upper respiratory infections and does not correlate with the severity of infectious mononucleosis. A low-grade fever can occur in many conditions and, when alone, does not indicate severity, as this illness can also present with high fever along with more serious systemic manifestations. Thus