Which of the following describes the mechanism of action of thiazolidinediones like rosiglitazone?

Thiazolidinediones, such as rosiglitazone, primarily improve insulin sensitivity and glucose uptake in tissues, particularly in muscle and adipose tissue. This class of medications acts as agonists for peroxisome proliferator-activated receptor-gamma (PPAR-γ), which plays a critical role in regulating glucose and lipid metabolism. By activating PPAR-γ, these drugs promote the transcription of genes involved in insulin action and glucose metabolism, leading to enhanced insulin sensitivity.

As a result, individuals taking thiazolidinediones can better utilize insulin's effects, ultimately lowering blood glucose levels and improving overall metabolic control. This mechanism distinguishes them from other medications that either increase insulin secretion, inhibit glucose absorption, or influence incretin hormones, which operate through different pathways in glucose regulation.